Recombinant Human F-box only protein 4 (FBXO4)

Uniprot Id

Q9UKT5

Target Species

Human

Target Name

FBXO4

Target Full Name

F-box only protein 4

Target Function

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.

Target Subcellular Location

Cytoplasm.

Target Research Area

Cell Biology

Target Synonyms

DKFZp547N213; F box only protein 4 ; F box protein 4; F box protein Fbx4; F-box only protein 4; FBX4; FBX4_HUMAN; FBXO 4; FBXO4; FLJ10141

Target Background

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.