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| Cat.No | ACP23858 | Target Name | F8A1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 2-371 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P23610 |
|---|
Uniprot Id
P23610
Target Species
Human
Target Name
F8A1
Target Full Name
40-kDa huntingtin-associated protein
Target Function
RAB5A effector molecule that is involved in vesicular trafficking of early endosomes. Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility.
Target Subcellular Location
Cytoplasm. Nucleus. Early endosome. Nucleus, nuclear body.
Target Tissue Specificity
Produced abundantly in a wide variety of cell types.
Target Synonyms
Coagulation factor 8 associated (intronic transcript) 1; Coagulation factor VIII associated (intronic transcript) 1; CpG island protein; DXS522E; F8a; F8A1; F8A2; F8A3; F8I2_HUMAN; Factor 8 associated protein; Factor 8 intron 22 protein; Factor VIII associated protein; Factor VIII intron 22 protein; huntingtin associated protein 40
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