Recombinant Human Fasciculation and elongation protein zeta-1 (FEZ1)

Uniprot Id

Q99689

Target Species

Human

Target Name

FEZ1

Target Full Name

Fasciculation and elongation protein zeta-1

Target Function

May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.

Target Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane.

Target Protein Families

Zygin family

Target Tissue Specificity

Mainly expressed in brain.

Target Synonyms

FEZ1Fasciculation and elongation protein zeta-1; Zygin I; Zygin-1

Target Background

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.