Recombinant Human Fc receptor-like protein 4 (FCRL4)

Cat.No	ACP03741	Target Name	FCRL4
Form	Liquid or Lyophilized powder	Expression System	Mammalian cell
Expression Range	20-387aa	Mol Weight	45.6kDa
Protein Length	Full Length of Mature Protein	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03741

Target Name

FCRL4

Form

Liquid or Lyophilized powder

Expression System

Mammalian cell

Expression Range

20-387aa

Mol Weight

45.6kDa

Protein Length

Full Length of Mature Protein

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q96PJ5

Background Information

Uniprot Id

Q96PJ5
Target Species

Human
Target Name

FCRL4
Target Full Name

Fc receptor-like protein 4
Target Function

May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.
Target Involvement

A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.
Target Tissue Specificity

Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level).
Target Research Area

Immunology
Target Synonyms

CD307d; Fc receptor homolog 4; Fc receptor like 4; Fc receptor like protein 4; Fc receptor-like protein 4; FcR like protein 4; FcR-like protein 4; FcRH4; FcRL4; FCRL4_HUMAN; hIFGP2; IFGP family protein 2; IGFP2; Immune receptor translocation associated protein 1; Immune receptor translocation-associated protein 1; Immunoglobulin superfamily receptor translocation associated 1; Immunoglobulin superfamily receptor translocation associated gene 1; IRTA1
Target Background

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma.

Recombinant Human Fc receptor-like protein 4 (FCRL4)

Specifications

Immunogen Information

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