Recombinant Human Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2), Truncated

Uniprot Id

Q9UPI3

Target Species

Human

Target Name

FLVCR2

Target Full Name

Choline/ethanolamine transporter FLVCR2

Target Function

Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism.

Target Involvement

Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Major facilitator superfamily, Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family

Target Tissue Specificity

Expressed in non-hematopoietic tissues, with relative abundant expression in brain, placenta, lung, liver and kidney. Also expressed in hematopoietic tissues (fetal liver, spleen, lymph node, thymus, leukocytes and bone marrow). Found in acidophil cells o

Target Synonyms

FLVCR2; C14orf58Feline leukemia virus subgroup C receptor-related protein 2; Calcium-chelate transporter; CCT

Target Background

This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.