Recombinant Human FGGY carbohydrate kinase domain-containing protein (FGGY)

Uniprot Id

Q96C11

Target Species

Human

Target Name

FGGY

Target Full Name

FGGY carbohydrate kinase domain-containing protein

Target Function

Catalyzes ATP-dependent phosphorylation of D-ribulose at C-5 to form D-ribulose 5-phosphate. Postulated to function in a metabolite repair mechanism by preventing toxic accumulation of free D-ribulose formed by non-specific phosphatase activities. Alternatively, may play a role in regulating D-ribulose 5-phosphate recycling in the pentose phosphate pathway. Can phosphorylate ribitol with low efficiency.

Target Involvement

Amyotrophic lateral sclerosis (ALS)

Target Protein Families

FGGY kinase family

Target Tissue Specificity

Expressed in kidney, lung and small intestine and to a lower extent in liver and detected in cerebrospinal fluid (at protein level).

Target Synonyms

FGGYFGGY carbohydrate kinase domain-containing protein; EC 2.7.1.-

Target Background

This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sclerosis, but studies of other populations have not been able to replicate this association. Alternative splicing results in multiple transcript variants.