Recombinant Human FH1/FH2 domain-containing protein 1 (FHOD1), Truncated

Uniprot Id

Q9Y613

Target Species

Human

Target Name

FHOD1

Target Full Name

FH1/FH2 domain-containing protein 1

Target Function

Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic.

Target Protein Families

Formin homology family

Target Tissue Specificity

Ubiquitous. Highly expressed in spleen.

Target Synonyms

FH1/FH2 domain containing protein ; FH1/FH2 domain containing protein 1; FH1/FH2 domain-containing protein 1; Fhod1; FHOD1_HUMAN; FHOS; FHOS1; Formin homolog overexpressed in spleen 1; Formin homology 2 domain containing 1; Formin homology 2 domain containing protein 1 ; Formin homology 2 domain-containing protein 1

Target Background

This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. Alternative splicing results in multiple transcript variants.