Recombinant Human Fibroblast growth factor 10 (FGF10)

Uniprot Id

O15520

Target Species

Human

Target Name

FGF10

Target Full Name

Fibroblast growth factor 10

Target Function

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

Target Involvement

Aplasia of lacrimal and salivary glands (ALSG); Lacrimo-auriculo-dento-digital syndrome (LADDS)

Target Subcellular Location

Secreted.

Target Protein Families

Heparin-binding growth factors family

Target Research Area

Cardiovascular

Target Synonyms

BB213776 ; fd11d03; FGF 10; FGF-10; FGF10; FGF10_HUMAN; Fibroblast growth factor 10; Keratinocyte growth factor 2; KGF 2; Produced by fibroblasts of urinary bladder lamina propria; wu:fd11d03; zgc:109774

Target Background

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing.