Recombinant Human Fibrocystin (PKHD1), Truncated

Cat.No	ACP20053	Target Name	PKHD1
Target Synonyms	ARPKD; FCYT; Fibrocystin; FPC; PKHD1; PKHD1_HUMAN; Polycystic kidney and hepatic disease 1 protein; Polyductin; TIGM1; Tigmin	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP20053

Target Name

PKHD1

Target Synonyms

ARPKD; FCYT; Fibrocystin; FPC; PKHD1; PKHD1_HUMAN; Polycystic kidney and hepatic disease 1 protein; Polyductin; TIGM1; Tigmin

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P08F94

Background Information

Uniprot Id

P08F94
Target Species

Human
Target Name

PKHD1
Target Full Name

Fibrocystin
Target Function

Promotes ciliogenesis in renal epithelial cells and therefore participates in the tubules formation and/ or ensures the maintenance of the architecture of the lumen of the kidney. Has an impact on cellular symmetry by ensuring correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly and by maintaining oriented cell division (OCD) during tubular elongation through planar cell polarity (PCP) pathway. During epithelial cell morphogenesis regulates also cell-cell and cell-matrix adhesion and participates in cell motility. Promotes cell-cell contact through the positive regulation of PTK2 kinase activity leading to either positive regulation of epithelial cell proliferation through the HRAS/RAF1 pathways, or negative regulation of apoptosis through the PDK1/AKT1 pathway. May act in collecting-duct and biliary differentiation. May participate in the regulation of the cholangiocytes proliferation and the CCN2 production in an CXCL8-dependent manner.
Target Involvement

Polycystic kidney disease 4, with or without hepatic disease (PKD4)
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere. Apical cell membrane. Nucleus. Secreted, extracellular exosome. Secreted. Endoplasmic reticulum. Golgi apparatus.
Target Tissue Specificity

Predominantly expressed in fetal and adult kidney. In the kidney, it is found in the cortical and medullary collecting ducts. Also present in the adult pancreas, but at much lower levels. Detectable in fetal and adult liver. Rather indistinct signal in fe
Target Synonyms

ARPKD; FCYT; Fibrocystin; FPC; PKHD1; PKHD1_HUMAN; Polycystic kidney and hepatic disease 1 protein; Polyductin; TIGM1; Tigmin

Recombinant Human Fibrocystin (PKHD1), Truncated

Specifications

Immunogen Information

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