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The recombinant human fibronectin type III domain-containing protein 5 (FNDC5) is produced in E.coli with the gene fragment corresponding to amino acids 32-143 of the human FNDC5. It is fused with a 6xHis-SUMO tag at the N-terminus. The 6xHis-SUMO motif is conducive to the generation of high-yield soluble, functional recombinant protein. The purity of this recombinant FNDC5 protein is greater than 90% measured by SDS-PAGE. It migrated to the molecular weight band of about 33 kDa on the gel. The target protein FNDC5 is a glycosylated type I membrane protein that produces a myokine irisin in response to exercise. Irisin travels to white adipose tissue and induces browning.
The recombinant human fibronectin type III domain-containing protein 5 (FNDC5) is produced in E.coli with the gene fragment corresponding to amino acids 32-143 of the human FNDC5. It is fused with a 6xHis-SUMO tag at the N-terminus. The 6xHis-SUMO motif is conducive to the generation of high-yield soluble, functional recombinant protein. The purity of this recombinant FNDC5 protein is greater than 90% measured by SDS-PAGE. It migrated to the molecular weight band of about 33 kDa on the gel. The target protein FNDC5 is a glycosylated type I membrane protein that produces a myokine irisin in response to exercise. Irisin travels to white adipose tissue and induces browning.
| Cat.No | ACP03703 | Target Name | FNDC5 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 32-143aa | Mol Weight | 28.6kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8NAU1 |
|---|
Uniprot Id
Q8NAU1
Target Species
Human
Target Name
FNDC5
Target Full Name
Fibronectin type III domain-containing protein 5
Target Function
Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein.; [Irisin]: Secreted.
Target Tissue Specificity
Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen.
Target Research Area
Cell Biology
Target Synonyms
Fibronectin type III domain containing 5; Fibronectin type III domain-containing protein 5; Fibronectin type III repeat containing protein 2; Fibronectin type III repeat-containing protein 2; FNDC 5; Fndc5; FNDC5_HUMAN; FRCP2; irisin
Target Background
This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants.
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