Recombinant Human Filamin-A (FLNA), Truncated

Uniprot Id

P21333

Target Species

Human

Target Name

FLNA

Target Full Name

Filamin-A

Target Function

Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance. During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons.

Target Involvement

Periventricular nodular heterotopia 1 (PVNH1); Otopalatodigital syndrome 1 (OPD1); Otopalatodigital syndrome 2 (OPD2); Frontometaphyseal dysplasia 1 (FMD1); Melnick-Needles syndrome (MNS); Intestinal pseudoobstruction, neuronal, chronic idiopathic, X-linked (IPOX); FG syndrome 2 (FGS2); Terminal osseous dysplasia (TOD); Cardiac valvular dysplasia X-linked (CVDX); Congenital short bowel syndrome, X-linked (CSBSX)

Target Subcellular Location

Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Perikaryon. Cell projection, growth cone.

Target Protein Families

Filamin family

Target Tissue Specificity

Ubiquitous.

Target Research Area

Signal Transduction

Target Synonyms

ABP 280 ; ABP-280; Actin-binding protein 280; Alpha filamin; Alpha-filamin; APBX; CSBS; CVD1; Endothelial actin binding protein; Endothelial actin-binding protein; Filamin 1; Filamin A alpha; Filamin A; Filamin-1; Filamin-A; FLN; FLN-A; FLN1; FLNA; FLNA_HUMAN; FMD; MNS; NHBP; Non muscle filamin ; Non-muscle filamin; OPD; OPD1; OPD2; XLVD; XMVD

Target Background

The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.