Recombinant Human Flavin reductase (NADPH) (BLVRB)

Uniprot Id

P30043

Target Species

Human

Target Name

BLVRB

Target Full Name

Flavin reductase (NADPH)

Target Function

Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.

Target Subcellular Location

Cytoplasm.

Target Tissue Specificity

Predominantly expressed in liver and erythrocytes. At lower levels in heart, lung, adrenal gland and cerebrum.

Target Synonyms

Biliverdin IX beta reductase; biliverdin reductase B (flavin reductase (NADPH)); Biliverdin reductase B; Biliverdin-IX beta-reductase; BLVRB; BLVRB_HUMAN; BVR B; BVR-B; BVRB; epididymis secretory protein Li 10; Flavin reductase (NADPH); Flavin reductase; FLR; FR; GHBP; Green heme binding protein; Green heme-binding protein; HEL-S-10; Methemoglobin reductase; MGC117413; NADPH dependent diaphorase; NADPH flavin reductase; NADPH-dependent diaphorase; NADPH-flavin reductase; SDR43U1; short chain dehydrogenase/reductase family 43U; member 1

Target Background

Enables biliverdin reductase (NAD(P)+) activity and riboflavin reductase (NADPH) activity. Involved in heme catabolic process. Located in cytosol; nucleoplasm; and plasma membrane.