Recombinant Human Follistatin-related protein 1 (FSTL1)

Uniprot Id

Q12841

Target Species

Human

Target Name

FSTL1

Target Full Name

Follistatin-related protein 1

Target Function

Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation. Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter. Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes. Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors.

Target Subcellular Location

Secreted.

Target Tissue Specificity

Overexpressed in synovial tissues from rheumatoid arthritis.

Target Synonyms

Anti FSTL1; FLJ50214; FLJ52277; Follistatin like 1; Follistatin related protein ; Follistatin-like protein 1; Follistatin-related protein 1; FRP; FSL1; FSTL1; FSTL1; FSTL1_HUMAN; Micro RNA 198; MIR198; miRNA198 included; OCC 1; OCC1

Target Background

This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis.