Recombinant Human Forkhead box protein L2 (FOXL2)

The expression region of this recombinant Human FOXL2 covers amino acids 1-376. The expected molecular weight for the FOXL2 protein is calculated to be 43.8 kDa. Expression of this FOXL2 protein is conducted in e.coli. The FOXL2 coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant FOXL2 protein in following stages of expression and purification.The human forkhead box protein L2 (FOXL2) is a transcription factor that plays a crucial role in various developmental processes, particularly in the development of ovarian tissues. FOXL2 is prominently expressed in ovarian granulosa cells, contributing to ovarian function and folliculogenesis. Mutations in the FOXL2 gene are associated with blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES), a genetic disorder characterized by eyelid malformations and ovarian dysfunction in affected females. Beyond its developmental role, FOXL2 is implicated in maintaining granulosa cell identity and suppressing male-specific gene expression in ovarian tissues. Understanding FOXL2's functions is essential for unraveling the complexities of ovarian development and related genetic disorders.

ACP01045

The expression region of this recombinant Human FOXL2 covers amino acids 1-376. The expected molecular weight for the FOXL2 protein is calculated to be 43.8 kDa. Expression of this FOXL2 protein is conducted in e.coli. The FOXL2 coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant FOXL2 protein in following stages of expression and purification.The human forkhead box protein L2 (FOXL2) is a transcription factor that plays a crucial role in various developmental processes, particularly in the development of ovarian tissues. FOXL2 is prominently expressed in ovarian granulosa cells, contributing to ovarian function and folliculogenesis. Mutations in the FOXL2 gene are associated with blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES), a genetic disorder characterized by eyelid malformations and ovarian dysfunction in affected females. Beyond its developmental role, FOXL2 is implicated in maintaining granulosa cell identity and suppressing male-specific gene expression in ovarian tissues. Understanding FOXL2’s functions is essential for unraveling the complexities of ovarian development and related genetic disorders.

Number

Cat.No	ACP01045	Target Name	FOXL2
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-376aa	Mol Weight	43.8 kDa
Protein Length	Full length	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP01045

Target Name

FOXL2

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-376aa

Mol Weight

43.8 kDa

Protein Length

Full length

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P58012

Background Information

Uniprot Id

P58012
Target Species

Human
Target Name

FOXL2
Target Full Name

Forkhead box protein L2
Target Function

Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Is a regulator of CYP19 expression. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element. Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
Target Involvement

Blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES); Premature ovarian failure 3 (POF3)
Target Subcellular Location

Nucleus.
Target Tissue Specificity

In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary.
Target Research Area

Others
Target Synonyms

Blepharophimosis; Blepharophimosis epicanthus inversus and ptosis 1; Blepharophimosis epicanthus inversus and ptosis; BPES 1; BPES; BPES1; Epicanthus inversus and ptosis 1; Forkhead box L2; Forkhead box protein L2; Forkhead transcription factor FOXL2; FOX L2; FOXL 2; FOXL2; FOXL2_HUMAN; PFRK; PINTO; PITUITARY FORKHEAD FACTOR; POF 3; POF3
Target Background

This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3.

Recombinant Human Forkhead box protein L2 (FOXL2)

Specifications

Immunogen Information

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