Recombinant Human Formin-2 (FMN2), Truncated

Cat.No	ACP00566	Target Name	FMN2
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1284-1722aa	Mol Weight	57.7 kDa
Protein Length	Partial	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP00566

Target Name

FMN2

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1284-1722aa

Mol Weight

57.7 kDa

Protein Length

Partial

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9NZ56

Background Information

Uniprot Id

Q9NZ56
Target Species

Human
Target Name

FMN2
Target Full Name

Formin-2
Target Function

Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. Protects cells against apoptosis by protecting CDKN1A against degradation.
Target Involvement

Mental retardation, autosomal recessive 47 (MRT47)
Target Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Nucleus. Nucleus, nucleolus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex.
Target Protein Families

Formin homology family, Cappuccino subfamily
Target Tissue Specificity

Expressed almost exclusively in the developing and mature central nervous system.
Target Research Area

Cell Biology
Target Synonyms

FMN 2; Fmn2; FMN2_HUMAN; Formin 2; Formin-2

Recombinant Human Formin-2 (FMN2), Truncated

Specifications

Immunogen Information

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