Recombinant Human Formin-2 (FMN2), Truncated

Cat.No	ACP11407	Target Name	FMN2
Target Synonyms	FMN 2; Fmn2; FMN2_HUMAN; Formin 2; Formin-2	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP11407

Target Name

FMN2

Target Synonyms

FMN 2; Fmn2; FMN2_HUMAN; Formin 2; Formin-2

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9NZ56

Background Information

Uniprot Id

Q9NZ56
Target Species

Human
Target Name

FMN2
Target Full Name

Formin-2
Target Function

Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. Protects cells against apoptosis by protecting CDKN1A against degradation.
Target Involvement

Mental retardation, autosomal recessive 47 (MRT47)
Target Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Nucleus. Nucleus, nucleolus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex.
Target Protein Families

Formin homology family, Cappuccino subfamily
Target Tissue Specificity

Expressed almost exclusively in the developing and mature central nervous system.
Target Research Area

Cell Biology
Target Synonyms

FMN 2; Fmn2; FMN2_HUMAN; Formin 2; Formin-2

Recombinant Human Formin-2 (FMN2), Truncated

Specifications

Immunogen Information

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