Recombinant Human Four and a half LIM domains protein 3 (FHL3)

Uniprot Id

Q13643

Target Species

Human

Target Name

FHL3

Target Full Name

Four and a half LIM domains protein 3

Target Function

Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.

Target Subcellular Location

Nucleus. Cytoplasm.

Target Tissue Specificity

Expressed only in skeletal muscle.

Target Research Area

Tags & Cell Markers

Target Synonyms

FHL 3; FHL-3; Fhl3; FHL3_HUMAN; Four and a half LIM domains 3; Four and a half LIM domains protein 3; Skeletal muscle LIM protein 2; Skeletal muscle LIM-protein 2; SLIM-2; SLIM2

Target Background

The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene.