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| Cat.No | ACP01558 | Target Name | FLI1 |
|---|---|---|---|
| Target Synonyms | (Proto-oncogene Fli-1)(Transcription factor ERGB) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-452aa |
| Mol Weight | 57.0 kDa | Protein Length | Full length |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q01543 |
|---|
Uniprot Id
Q01543
Target Species
Human
Target Name
FLI1
Target Full Name
Friend leukemia integration 1 transcription factor
Target Function
Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
Target Involvement
Ewing sarcoma (ES); Bleeding disorder, platelet-type 21 (BDPLT21)
Target Subcellular Location
Nucleus.
Target Protein Families
ETS family
Target Research Area
Cancer
Target Synonyms
(Proto-oncogene Fli-1)(Transcription factor ERGB)
Target Background
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
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