Recombinant Human FYVE, RhoGEF and PH domain-containing protein 4 (FGD4)

Cat.No	ACP14063	Target Name	FGD4
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-766	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP14063

Target Name

FGD4

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-766

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q96M96

Background Information

Uniprot Id

Q96M96
Target Species

Human
Target Name

FGD4
Target Full Name

FYVE, RhoGEF and PH domain-containing protein 4
Target Function

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8.
Target Involvement

Charcot-Marie-Tooth disease 4H (CMT4H)
Target Subcellular Location

Cytoplasm, cytoskeleton. Cell projection, filopodium.
Target Tissue Specificity

Expressed in different tissues, including brain, cerebellum, peripheral nerve, skeletal muscle, heart, uterus, placenta and testis.
Target Synonyms

9030023J02Rik; 9330209B17Rik; Actin filament binding protein frabin; Actin filament-binding protein frabin; CMT4H; DKFZp313E1818; DKFZp434K1572; FGD1 related F actin binding protein; FGD1-related F-actin-binding protein; Fgd4; FGD4_HUMAN; FLJ34370; FLJ42663; FRABP; FYVE; FYVE; RhoGEF and PH domain containing 4; MGC57222; RhoGEF and PH domain-containing protein 4; ZFYVE6; Zinc finger FYVE domain containing protein 6; Zinc finger FYVE domain-containing protein 6
Target Background

This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Recombinant Human FYVE, RhoGEF and PH domain-containing protein 4 (FGD4)

Specifications

Immunogen Information

Inquire Recombinant Human FYVE, RhoGEF and PH domain-containing protein 4 (FGD4) Now

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