Recombinant Human G-protein coupled receptor-associated sorting protein 1 (GPRASP1), Truncated

Uniprot Id

Q5JY77

Target Species

Human

Target Name

GPRASP1

Target Full Name

G-protein coupled receptor-associated sorting protein 1

Target Function

Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.

Target Subcellular Location

Cytoplasm.

Target Protein Families

GPRASP family

Target Tissue Specificity

Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.

Target Synonyms

G-protein coupled receptor-associated sorting protein 1; GASP; GASP-1; GASP1; GASP1_HUMAN; Gprasp1; KIAA0443

Target Background

This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified.