Recombinant Human G1/S-specific cyclin-E2 (CCNE2)

Uniprot Id

O96020

Target Species

Human

Target Name

CCNE2

Target Full Name

G1/S-specific cyclin-E2

Target Function

Essential for the control of the cell cycle at the late G1 and early S phase.

Target Subcellular Location

Nucleus.

Target Protein Families

Cyclin family, Cyclin E subfamily

Target Tissue Specificity

According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubM

Target Synonyms

CCNE2; G1/S-specific cyclin-E2

Target Background

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells.