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The production of this Recombinant Human GALC protein started with the GALC gene synthesis. And then using recombinant DNA technology, the GALC gene was inserted into an expression vector so that we could get the recombinant express plasmid of GALC. Transform the plasmid into the cells of Yeast, culture the cells and we could get the desired Recombinant Human GALC protein. But the work was not completed, protein purification and a strict QC system were performed in the last step. The purity is 90%+ determined by SDS-PAGE.GALC is a gene providing an instruction of making a protein named galactocerebrosidase (GALC) in human. The protein encoded by this gene has several alternative names, including galactocerebroside beta-galactosidase, galactosylceramidase1 and galactosylceramide beta-galactosidase. GALC protein is an enzyme that removes galactose from ceramide derivatives (galactosylceramides). This protein is involved in three biological processes, including galactosylceramide catabolic process, glycosphingolipid metabolic process and myelination.
The production of this Recombinant Human GALC protein started with the GALC gene synthesis. And then using recombinant DNA technology, the GALC gene was inserted into an expression vector so that we could get the recombinant express plasmid of GALC. Transform the plasmid into the cells of Yeast, culture the cells and we could get the desired Recombinant Human GALC protein. But the work was not completed, protein purification and a strict QC system were performed in the last step. The purity is 90%+ determined by SDS-PAGE.GALC is a gene providing an instruction of making a protein named galactocerebrosidase (GALC) in human. The protein encoded by this gene has several alternative names, including galactocerebroside beta-galactosidase, galactosylceramidase1 and galactosylceramide beta-galactosidase. GALC protein is an enzyme that removes galactose from ceramide derivatives (galactosylceramides). This protein is involved in three biological processes, including galactosylceramide catabolic process, glycosphingolipid metabolic process and myelination.
| Cat.No | ACP04745 | Target Name | GALC |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Yeast |
| Expression Range | 43-685aa | Mol Weight | 74.8kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P54803 |
|---|
Uniprot Id
P54803
Target Species
Human
Target Name
GALC
Target Full Name
Galactocerebrosidase
Target Function
Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
Target Involvement
Leukodystrophy, globoid cell (GLD)
Target Subcellular Location
Lysosome.
Target Protein Families
Glycosyl hydrolase 59 family
Target Tissue Specificity
Detected in urine. Detected in testis, brain and placenta (at protein level). Detected in kidney and liver.
Target Research Area
Cardiovascular
Target Synonyms
Gacy; Galactocerebrosidase; Galactocerebroside beta galactosidase; Galactocerebroside beta-galactosidase; Galactosylceramidase; Galactosylceramide beta galactosidase; Galactosylceramide beta-galactosidase; galactosylceraminidase; GALC; GALC_HUMAN; GALCERase; Twitcher
Target Background
This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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