Recombinant Human Galactoside 2-alpha-L-fucosyltransferase 1 (FUT1), Truncated

Uniprot Id

P19526

Target Species

Human

Target Name

FUT1

Target Full Name

Galactoside alpha-(1,2)-fucosyltransferase 1

Target Function

Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens. H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis. Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a.

Target Subcellular Location

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Target Protein Families

Glycosyltransferase 11 family

Target Synonyms

FUT1; H; HSC; Galactoside alpha-(1,2-fucosyltransferase 1; Alpha(1,2FT 1; Blood group H alpha 2-fucosyltransferase; Fucosyltransferase 1; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1; Type 1 galactoside alpha-(1,2-fucosyltransferase FUT1; Type 2 galactoside alpha-(1,2-fucosyltransferase FUT1

Target Background

This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group.