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The region for expressing recombinant Human GABRB2 contains amino acids 26-244. The calculated molecular weight for this GABRB2 protein is 29.3 kDa. The GABRB2 protein was expressed in e.coli. The GABRB2 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant GABRB2 protein during the following stages.The human Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2) is a component of the GABAA receptor, a ligand-gated ion channel that plays a crucial role in inhibitory neurotransmission within the central nervous system. GABRB2 is involved in forming functional GABAergic receptors. Activation of these receptors by the neurotransmitter gamma-aminobutyric acid (GABA) leads to an influx of chloride ions, resulting in membrane hyperpolarization and neuronal inhibition. GABRB2's presence in the GABAA receptor complex contributes to the regulation of neuronal excitability and is implicated in various neurological and psychiatric disorders, making it a target of interest in pharmacological research and drug development.
The region for expressing recombinant Human GABRB2 contains amino acids 26-244. The calculated molecular weight for this GABRB2 protein is 29.3 kDa. The GABRB2 protein was expressed in e.coli. The GABRB2 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant GABRB2 protein during the following stages.The human Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2) is a component of the GABAA receptor, a ligand-gated ion channel that plays a crucial role in inhibitory neurotransmission within the central nervous system. GABRB2 is involved in forming functional GABAergic receptors. Activation of these receptors by the neurotransmitter gamma-aminobutyric acid (GABA) leads to an influx of chloride ions, resulting in membrane hyperpolarization and neuronal inhibition. GABRB2’s presence in the GABAA receptor complex contributes to the regulation of neuronal excitability and is implicated in various neurological and psychiatric disorders, making it a target of interest in pharmacological research and drug development.
| Cat.No | ACP02092 | Target Name | GABRB2 |
|---|---|---|---|
| Target Synonyms | GABA(A) receptor subunit beta-2 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 26-244aa |
| Mol Weight | 29.3 kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P47870 |
|---|
Uniprot Id
P47870
Target Species
Human
Target Name
GABRB2
Target Full Name
Gamma-aminobutyric acid receptor subunit beta-2
Target Function
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine.
Target Subcellular Location
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.
Target Protein Families
Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRB2 sub-subfamily
Target Tissue Specificity
Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.
Target Research Area
Neuroscience, More proteins and peptides
Target Synonyms
GABA; GABA(A) receptor beta 2; GABA(A) receptor subunit beta-2; GABA-A receptor, beta-2 polypeptide; GABRB2; Gamma aminobutyric acid (GABA) A receptor, beta 2; Gamma aminobutyric acid A receptor beta 2; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric-acid receptor subunit beta-2; GBRB2_HUMAN
Target Background
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion.
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