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Recombinant Human Gamma-secretase-activating protein (PION)

ACP22028

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Specifications

Cat.No	ACP22028	Target Name	GSAP
Target Synonyms	A530088I07Rik; DKFZp667B242; Gamma-secretase-activating protein 16 kDa C-terminal form; GSAP; GSAP-16K; GSAP_HUMAN; MGC126548; Pigeon homolog (Drosophila) ; Pion; Protein pigeon homolog; tcag7.1314	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	A4D1B5

Background Information

Uniprot Id

A4D1B5
Target Species

Human
Target Name

GSAP
Target Full Name

Gamma-secretase-activating protein
Target Function

Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD
Target Subcellular Location

Golgi apparatus, trans-Golgi network.
Target Protein Families

GSAP family
Target Tissue Specificity

Widely expressed.
Target Synonyms

A530088I07Rik; DKFZp667B242; Gamma-secretase-activating protein 16 kDa C-terminal form; GSAP; GSAP-16K; GSAP_HUMAN; MGC126548; Pigeon homolog (Drosophila) ; Pion; Protein pigeon homolog; tcag7.1314

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Recombinant Human Gamma-secretase-activating protein (PION)

Specifications

Immunogen Information

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