Recombinant Human GDP-L-fucose synthase (GFUS)

Uniprot Id

Q13630

Target Species

Human

Target Name

GFUS

Target Full Name

GDP-L-fucose synthase

Target Function

Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

Target Protein Families

NAD(P)-dependent epimerase/dehydratase family, Fucose synthase subfamily

Target Synonyms

3 5 epimerase/4 reductase; 5-epimerase-4-reductase; anti TSTA3; EC 1.1.1.271; FCL_HUMAN; FX; GDP 4 keto 6 deoxy D mannose 3 5 epimerase 4 reductase; GDP 4 keto 6 deoxy D mannose epimerase reductase; GDP L fucose synthase; GDP-4-keto-6-deoxy-D-mannose-3; GDP-L-fucose synthase; P35B; Protein FX; Red cell NADP(H) binding protein; Red cell NADP(H)-binding protein; SDR4E1; Short chain dehydrogenase/reductase family 4E member 1; Short-chain dehydrogenase/reductase family 4E member 1; Tissue specific transplantation antigen 3; Tissue specific transplantation antigen P35B; TSTA3; TSTA3

Target Background

Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II.