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| Cat.No | ACP21192 | Target Name | GMDS |
|---|---|---|---|
| Target Synonyms | 6 dehydratase; GMD; Gmds; GMDS_HUMAN; OTTHUMP00000017756; OTTHUMP00000232770; SDR3E1; Short chain dehydrogenase/reductase family 3E member 1, GDP D mannose dehydratase; GDP mannose 4 6 dehydratase; GDP-D-mannose dehydratase; GDP-mannose 4 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 2-372 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O60547 |
|---|
Uniprot Id
O60547
Target Species
Human
Target Name
GMDS
Target Full Name
GDP-mannose 4,6 dehydratase
Target Function
Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
Target Protein Families
NAD(P)-dependent epimerase/dehydratase family, GDP-mannose 4,6-dehydratase subfamily
Target Synonyms
GDP D mannose dehydratase; GDP mannose 4 6 dehydratase; GDP-D-mannose dehydratase; GDP-mannose 4,6 dehydratase; GMD; Gmds; GMDS_HUMAN; OTTHUMP00000017756; OTTHUMP00000232770; SDR3E1; Short chain dehydrogenase/reductase family 3E member 1
Target Background
GDP-mannose 4, 6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3, 5-epimerase, 4-reductase, designated FX in humans (MIM 137020).
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