Recombinant Human General transcription factor 3C polypeptide 6 (GTF3C6)

Uniprot Id

Q969F1

Target Species

Human

Target Name

GTF3C6

Target Full Name

General transcription factor 3C polypeptide 6

Target Function

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

Target Subcellular Location

Nucleus.

Target Protein Families

TFIIIC subunit 6 family

Target Synonyms

GTF3C6; C6orf51; CDA020; NPD020; General transcription factor 3C polypeptide 6; Transcription factor IIIC 35 kDa subunit; TFIIIC 35 kDa subunit; TFIIIC35; Transcription factor IIIC subunit 6

Target Background

RNA polymerases are unable to initiate RNA synthesis in the absence of additional proteins called general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1, MIM 603246) are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA (MIM 180420), tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin.