Recombinant Human General transcription factor IIH subunit 5 (GTF2H5)

Uniprot Id

Q6ZYL4

Target Species

Human

Target Name

GTF2H5

Target Full Name

General transcription factor IIH subunit 5

Target Function

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.

Target Involvement

Trichothiodystrophy 3, photosensitive (TTD3)

Target Subcellular Location

Nucleus. Cytoplasm.

Target Protein Families

TFB5 family

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

GTF2H5; C6orf175; TTDA; General transcription factor IIH subunit 5; General transcription factor IIH polypeptide 5; TFB5 ortholog; TFIIH basal transcription factor complex TTD-A subunit