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The expression of recombinant Human GLP2R protein involves transfecting mammalian cells with a DNA expression vector carrying the gene for the protein of interest (1-173aa). After transfection, the cells are cultured to produce the desired protein. A C-terminal 10xHis tag is fused to the protein. The recombinant Human GLP2R protein is collected and purified from the cell lysate through affinity purification, attaining a purity greater than 85%, as determined by SDS-PAGE.
The expression of recombinant Human GLP2R protein involves transfecting mammalian cells with a DNA expression vector carrying the gene for the protein of interest (1-173aa). After transfection, the cells are cultured to produce the desired protein. A C-terminal 10xHis tag is fused to the protein. The recombinant Human GLP2R protein is collected and purified from the cell lysate through affinity purification, attaining a purity greater than 85%, as determined by SDS-PAGE.
| Cat.No | ACP01243 | Target Name | GLP2R |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Mammalian cell |
| Expression Range | 1-173aa | Mol Weight | 22.0 kDa |
| Protein Length | Partial | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O95838 |
|---|
Uniprot Id
O95838
Target Species
Human
Target Name
GLP2R
Target Full Name
Glucagon-like peptide 2 receptor
Target Function
This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 2 family
Target Research Area
Cell Biology
Target Synonyms
GLP2R; Glucagon-like peptide 2 receptor; GLP-2 receptor; GLP-2-R; GLP-2R
Target Background
This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis.
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