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| Cat.No | ACP05355 | Target Name | GRIN3B |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O60391 |
|---|
Uniprot Id
O60391
Target Species
Human
Target Name
GRIN3B
Target Full Name
Glutamate receptor ionotropic, NMDA 3B
Target Function
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane.
Target Protein Families
Glutamate-gated ion channel (TC 1.A.10.1) family, NR3B/GRIN3B subfamily
Target Synonyms
GluN3B; Glutamate [NMDA] receptor subunit 3B; Glutamate receptor ionotropic N methyl D aspartate 3B ; Glutamate receptor ionotropic NMDA 3B; GRIN3B; N-methyl-D-aspartate receptor subtype 3B; NMD3B_HUMAN; NMDA receptor subunit 3B; NMDA type glutamate receptor subunit NR3B; NMDAR3B; NR3B
Target Background
The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia.
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