Recombinant Human Glutamate receptor, ionotropic kainate 2 (GRIK2), Truncated

Uniprot Id

Q13002

Target Species

Human

Target Name

GRIK2

Target Full Name

Glutamate receptor ionotropic, kainate 2

Target Function

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. Modulates cell surface expression of NETO2.; Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures. Functions in dorsal root ganglion neurons.

Target Involvement

Mental retardation, autosomal recessive 6 (MRT6)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Target Protein Families

Glutamate-gated ion channel (TC 1.A.10.1) family, GRIK2 subfamily

Target Tissue Specificity

Expression is higher in cerebellum than in cerebral cortex.

Target Synonyms

bA487F5.1; EAA4; Excitatory amino acid receptor 4; GLR 6; GLR6; GluK2; GLUK6; GLUR 6; GluR-6; GluR6; Glutamate receptor 6; Glutamate receptor; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; Glutamate receptor ionotropic kainate 2; GRIK 2; GRIK2; GRIK2 protein; GRIK2_HUMAN; ionotropic kainate 2; MRT6

Target Background

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability.