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| Cat.No | ACP10371 | Target Name | QRSL1 |
|---|---|---|---|
| Target Synonyms | QRSL1; Glutamyl-tRNA(Gln) amidotransferase subunit A; mitochondrial; Glu-AdT subunit A; EC 6.3.5.7; Glutaminyl-tRNA synthase-like protein 1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-528 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9H0R6 |
|---|
Uniprot Id
Q9H0R6
Target Species
Human
Target Name
QRSL1
Target Full Name
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
Target Function
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Target Involvement
Defects in QRSL1 may play a role in mitochondrial disorders characterized by combined respiratory chain complex deficiencies.
Target Subcellular Location
Mitochondrion.
Target Protein Families
Amidase family, GatA subfamily
Target Synonyms
QRSL1; Glutamyl-tRNA(Gln) amidotransferase subunit A; mitochondrial; Glu-AdT subunit A; EC 6.3.5.7; Glutaminyl-tRNA synthase-like protein 1
Target Background
Enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidotransferase complex. Implicated in combined oxidative phosphorylation deficiency 40.
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