Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The recombinant human Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is expressed in E. coli using recombinant DNA technology. The expression region of the recombinant human includes the entire sequence of the mature human GAPDH protein (2-335aa), ensuring that the recombinant version retains all the functional domains and essential amino acid residues necessary for its biological activity. It carries an N-terminal 6xHis-SUMO tag, facilitating purification and enhancing protein expression and stability. Its purity is greater than 90% determined by SDS-PAGE. This recombinant human GAPDH protein can be utilized in neuroscience-related studies to investigate its enzymatic activity, protein-protein interactions, and cellular functions.
The recombinant human Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is expressed in E. coli using recombinant DNA technology. The expression region of the recombinant human includes the entire sequence of the mature human GAPDH protein (2-335aa), ensuring that the recombinant version retains all the functional domains and essential amino acid residues necessary for its biological activity. It carries an N-terminal 6xHis-SUMO tag, facilitating purification and enhancing protein expression and stability. Its purity is greater than 90% determined by SDS-PAGE. This recombinant human GAPDH protein can be utilized in neuroscience-related studies to investigate its enzymatic activity, protein-protein interactions, and cellular functions.
| Cat.No | ACP02418 | Target Name | GAPDH |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-335aa | Mol Weight | 51.9kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P04406 |
|---|
Uniprot Id
P04406
Target Species
Human
Target Name
GAPDH
Target Full Name
Glyceraldehyde-3-phosphate dehydrogenase
Target Function
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC.
Target Subcellular Location
Cytoplasm, cytosol. Nucleus. Cytoplasm, perinuclear region. Membrane. Cytoplasm, cytoskeleton.
Target Protein Families
Glyceraldehyde-3-phosphate dehydrogenase family
Target Research Area
Apoptosis, Neuroscience
Target Synonyms
38 kDa BFA-dependent ADP-ribosylation substrate; aging associated gene 9 protein; Aging-associated gene 9 protein; BARS-38; cb609; EC 1.2.1.12; Epididymis secretory sperm binding protein Li 162eP; G3P_HUMAN; G3PD; G3PDH; GAPD; GAPDH; Glyceraldehyde 3 phosphate dehydrogenase; glyceraldehyde 3-PDH; Glyceraldehyde-3-phosphate dehydrogenase; HEL-S-162eP; KNC-NDS6; MGC102544; MGC102546; MGC103190; MGC103191; MGC105239; MGC127711; MGC88685; OCAS; p38 component; OCT1 coactivator in S phase; 38-KD component; peptidyl cysteine S nitrosylase GAPDH; Peptidyl-cysteine S-nitrosylase GAPDH; wu:fb33a10
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
