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Enhance your apoptosis research with our high-quality Recombinant Human GAPDH protein. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a well-known enzyme involved in glycolysis and gluconeogenesis, playing a crucial role in cellular energy production. Beyond its metabolic functions, GAPDH has emerged as a key player in apoptosis, making it a valuable target for the study of cell death and survival mechanisms. Our Recombinant Human GAPDH protein is expressed in E.coli, resulting in a partial-length protein that encompasses the 3-335aa region. The N-terminal GST-tag enables efficient purification and detection for seamless integration into your experiments. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human GAPDH protein provides the reliability and consistency you need for your research endeavors. Choose from liquid or lyophilized powder forms to accommodate your laboratory's requirements, and trust our Recombinant Human GAPDH protein to drive your apoptosis research forward.
Enhance your apoptosis research with our high-quality Recombinant Human GAPDH protein. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a well-known enzyme involved in glycolysis and gluconeogenesis, playing a crucial role in cellular energy production. Beyond its metabolic functions, GAPDH has emerged as a key player in apoptosis, making it a valuable target for the study of cell death and survival mechanisms.
Our Recombinant Human GAPDH protein is expressed in E.coli, resulting in a partial-length protein that encompasses the 3-335aa region. The N-terminal GST-tag enables efficient purification and detection for seamless integration into your experiments. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human GAPDH protein provides the reliability and consistency you need for your research endeavors. Choose from liquid or lyophilized powder forms to accommodate your laboratory’s requirements, and trust our Recombinant Human GAPDH protein to drive your apoptosis research forward.
| Cat.No | ACP03087 | Target Name | GAPDH |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 3-335aa | Mol Weight | 62.9kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P04406 |
|---|
Uniprot Id
P04406
Target Species
Human
Target Name
GAPDH
Target Full Name
Glyceraldehyde-3-phosphate dehydrogenase
Target Function
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC.
Target Subcellular Location
Cytoplasm, cytosol. Nucleus. Cytoplasm, perinuclear region. Membrane. Cytoplasm, cytoskeleton.
Target Protein Families
Glyceraldehyde-3-phosphate dehydrogenase family
Target Research Area
Apoptosis, Neuroscience
Target Synonyms
38 kDa BFA-dependent ADP-ribosylation substrate; aging associated gene 9 protein; Aging-associated gene 9 protein; BARS-38; cb609; EC 1.2.1.12; Epididymis secretory sperm binding protein Li 162eP; G3P_HUMAN; G3PD; G3PDH; GAPD; GAPDH; Glyceraldehyde 3 phosphate dehydrogenase; glyceraldehyde 3-PDH; Glyceraldehyde-3-phosphate dehydrogenase; HEL-S-162eP; KNC-NDS6; MGC102544; MGC102546; MGC103190; MGC103191; MGC105239; MGC127711; MGC88685; OCAS; p38 component; OCT1 coactivator in S phase; 38-KD component; peptidyl cysteine S nitrosylase GAPDH; Peptidyl-cysteine S-nitrosylase GAPDH; wu:fb33a10
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