Recombinant Human GPN-loop GTPase 1 (GPN1)

Uniprot Id

Q9HCN4

Target Species

Human

Target Name

GPN1

Target Full Name

GPN-loop GTPase 1

Target Function

Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

GPN-loop GTPase family

Target Tissue Specificity

Expressed ubiquitously.

Target Synonyms

ATP(GTP) binding protein; ATPBD1A; FLJ51176; GPN loop GTPase 1; GPN-loop GTPase 1; Gpn1; GPN1_HUMAN; MBD2 interacting protein; MBD2-interacting protein; MBDin; NTPBP; RNA polymerase II associated protein 4; RPAP4; XAB1; XPA binding protein 1; XPA binding protein 1 GTPase; XPA-binding protein 1

Target Background

This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described.