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| Cat.No | ACP03614 | Target Name | GCA |
|---|---|---|---|
| Target Synonyms | GCA; GCL; Grancalcin | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-217aa |
| Mol Weight | 51.0kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P28676 |
|---|
Uniprot Id
P28676
Target Species
Human
Target Name
GCA
Target Full Name
Grancalcin
Target Function
Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.
Target Subcellular Location
Cytoplasm. Cytoplasmic granule membrane; Peripheral membrane protein; Cytoplasmic side.
Target Tissue Specificity
Detected in neutrophils and macrophages (at protein level). Highly expressed in bone marrow.
Target Research Area
others
Target Synonyms
GCA; GCL; Grancalcin
Target Background
This gene encodes a calcium-binding protein that is abundant in neutrophils and macrophages. In the absence of divalent cation, this protein localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions. Alternative splicing and use of alternative promoters results in multiple transcript variants.
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