Recombinant Human Growth arrest-specific protein 8 (GAS8)

Uniprot Id

O95995

Target Species

Human

Target Name

GAS8

Target Full Name

Dynein regulatory complex subunit 4

Target Function

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker. Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner.

Target Involvement

Ciliary dyskinesia, primary, 33 (CILD33)

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Golgi apparatus. Cell projection, cilium. Cytoplasm, cytoskeleton, flagellum axoneme.

Target Protein Families

DRC4 family

Target Tissue Specificity

Expressed in respiratory epithelial cells (at protein level). Expressed in the heart, skeletal muscle, pancreas, liver, brain, trachea and lung. Weakly or not expressed in placenta and kidney.

Target Synonyms

Growth arrest specific protein 8; MGC138326; GAS 11; GAS 8; GAS-11; GAS-8; GAS11; Gas8; GAS8_HUMAN; Growth arrest specific 11; Growth arrest specific 8; Growth arrest specific protein 11; Growth arrest-specific protein 11; Growth arrest-specific protein 8