Recombinant Human GTP-binding protein Rit1 (RIT1)

Uniprot Id

Q92963

Target Species

Human

Target Name

RIT1

Target Full Name

GTP-binding protein Rit1

Target Function

Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.

Target Involvement

Noonan syndrome 8 (NS8)

Target Subcellular Location

Cell membrane.

Target Protein Families

Small GTPase superfamily, Ras family

Target Tissue Specificity

Expressed in many tissues.

Target Synonyms

GTP binding protein Roc1; GTP-binding protein Rit1; NS8; Ras like protein expressed in many tissues; Ras like without CAAX 1; Ras-like protein expressed in many tissues; Ras-like without CAAX protein 1; RIBB; Ric like expressed in many tissues; Ric-like protein without CAAX motif 1; RIT; RIT1; RIT1_HUMAN; ROC1

Target Background

This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants.