Recombinant Human GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1), Truncated

Uniprot Id

Q14C86

Target Species

Human

Target Name

GAPVD1

Target Full Name

GTPase-activating protein and VPS9 domain-containing protein 1

Target Function

Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras

Target Subcellular Location

Membrane; Peripheral membrane protein. Endosome. Note=Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin.

Target Protein Families

GAPVD1 family

Target Synonyms

GAPVD1; GAPEX5; KIAA1521; RAP6GTPase-activating protein and VPS9 domain-containing protein 1; GAPex-5; Rab5-activating protein 6