Recombinant Human Guanine nucleotide-binding protein G (olf) subunit alpha (GNAL)

Uniprot Id

P38405

Target Species

Human

Target Name

GNAL

Target Full Name

Guanine nucleotide-binding protein G(olf) subunit alpha

Target Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.

Target Involvement

Dystonia 25 (DYT25)

Target Protein Families

G-alpha family, G(s) subfamily

Target Tissue Specificity

Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined.

Target Synonyms

Adenylate cyclase stimulating G alpha protein; olfactory type; Adenylate cyclase-stimulating G alpha protein; DYT25; G alpha olf; Gnal; GNAL_HUMAN; Guanine nucleotide binding protein (G protein); alpha activating activity polypeptide; olfactory type; Guanine nucleotide binding protein (G protein); alpha stimulating activity polypeptide; olfactory type ; Guanine nucleotide binding protein G(olf) subunit alpha ; Guanine nucleotide-binding protein G(olf) subunit alpha; olfactory type

Target Background

This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants.