Recombinant Human Guanylate cyclase activator 2B (GUCA2B)

Uniprot Id

Q16661

Target Species

Human

Target Name

GUCA2B

Target Full Name

Guanylate cyclase activator 2B

Target Function

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.

Target Subcellular Location

Secreted.

Target Protein Families

Guanylin family

Target Tissue Specificity

Stomach and intestine.

Target Research Area

Signal Transduction

Target Synonyms

GUCA2B; GCAP II; GCAP-II; Guanylate cyclase activator 2B (uroguanylin); Guanylate cyclase activator 2B; Guanylate cyclase C-activating peptide II; GUC2B_HUMAN; GUCA2B; UGN; Uroguanylin

Target Background

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys.