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Recombinant Human Guanylate kinase (GUK1)

ACP03717

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Specifications

Cat.No	ACP03717	Target Name	GUK1
Target Synonyms	ATP:GMP phosphotransferase; FLJ42686; FLJ43710; GMK; GMP kinase; Guanylate kinase; GUK1; KGUA_HUMAN	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	2-197aa
Mol Weight	37.6kDa	Protein Length	Full Length of Mature Protein
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q16774

Background Information

Uniprot Id

Q16774
Target Species

Human
Target Name

GUK1
Target Full Name

Guanylate kinase
Target Function

Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. It may also have a role in the survival and growth progression of some tumors. In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine.
Target Subcellular Location

Photoreceptor inner segment. Cytoplasm, cytosol.
Target Protein Families

Guanylate kinase family
Target Tissue Specificity

Widely expressed.
Target Research Area

Cancer
Target Synonyms

ATP:GMP phosphotransferase; FLJ42686; FLJ43710; GMK; GMP kinase; Guanylate kinase; GUK1; KGUA_HUMAN
Target Background

The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene.

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Recombinant Human Guanylate kinase (GUK1)

Specifications

Immunogen Information

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