Recombinant Human H (+)/Cl (-) exchange transporter 3 (CLCN3), Truncated

Uniprot Id

P51790

Target Species

Human

Target Name

CLCN3

Target Full Name

H(+)/Cl(-) exchange transporter 3

Target Function

Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.; Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons.

Target Subcellular Location

[Isoform 1]: Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.; [Isoform 2]: Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, ruffle membrane; Multi-pass membrane protein.

Target Protein Families

Chloride channel (TC 2.A.49) family, ClC-3/CLCN3 subfamily

Target Tissue Specificity

Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic

Target Synonyms

CLCN3; H(+/Cl(- exchange transporter 3; Chloride channel protein 3; ClC-3; Chloride transporter ClC-3