Recombinant Human HBS1-like protein (HBS1L)

Cat.No	ACP09699	Target Name	HBS1L
Target Synonyms	EF 1a; ERF3 similar protein; ERFS; HBS1; HBS1 like; HBS1 like protein; HBS1, homolog of; HBS1-like (S. cerevisiae); HBS1-like protein; Hbs1l; HBS1L_HUMAN; Hsp70 subfamily B suppressor 1 like protein; HSPC276; KIAA1038, S. cerevisiae	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-684
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP09699

Target Name

HBS1L

Target Synonyms

EF 1a; ERF3 similar protein; ERFS; HBS1; HBS1 like; HBS1 like protein; HBS1, homolog of; HBS1-like (S. cerevisiae); HBS1-like protein; Hbs1l; HBS1L_HUMAN; Hsp70 subfamily B suppressor 1 like protein; HSPC276; KIAA1038, S. cerevisiae

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-684

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9Y450

Background Information

Uniprot Id

Q9Y450
Target Species

Human
Target Name

HBS1L
Target Full Name

HBS1-like protein
Target Function

Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. In the presence of ABCE1 and PELO, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with PELO and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway.; Facilitates the association of the exosome complex with the SKI complex.
Target Subcellular Location

[Isoform 2]: Cytoplasm.
Target Protein Families

TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family
Target Tissue Specificity

Detected in heart, brain, placenta, liver, muscle, kidney and pancreas.
Target Synonyms

EF 1a; ERF3 similar protein; ERFS; HBS1; HBS1 like; HBS1 like protein; HBS1, S. cerevisiae, homolog of; HBS1-like (S. cerevisiae); HBS1-like protein; Hbs1l; HBS1L_HUMAN; Hsp70 subfamily B suppressor 1 like protein; HSPC276; KIAA1038
Target Background

This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Recombinant Human HBS1-like protein (HBS1L)

Specifications

Immunogen Information

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