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| Cat.No | ACP20584 | Target Name | HSF2BP |
|---|---|---|---|
| Target Synonyms | HSF2BP; Heat shock factor 2-binding protein | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-334 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O75031 |
|---|
Uniprot Id
O75031
Target Species
Human
Target Name
HSF2BP
Target Full Name
Heat shock factor 2-binding protein
Target Function
Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. Required for proper recombinase recruitment in female meiosis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm. May be involved in modulating HSF2 activation in testis
Target Subcellular Location
Cytoplasm. Chromosome.
Target Tissue Specificity
Testis specific. Overexpressed in some tumors.
Target Synonyms
HSF2BP; Heat shock factor 2-binding protein
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