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Amino acids 60-308 form the expressed segment for recombinant Human TRAP1. The theoretical molecular weight of the TRAP1 protein is 54.5 kDa. This TRAP1 recombinant protein is manufactured in e.coli. The N-terminal GST tag was fused into the coding gene segment of TRAP1, making it easier to detect and purify the TRAP1 recombinant protein in the later stages of expression and purification.The human heat shock protein 75 kDa, mitochondrial (TRAP1) is a molecular chaperone located in the mitochondria. TRAP1 belongs to the HSP90 family and plays a critical role in mitochondrial protein folding, stability, and cellular stress response. TRAP1 is involved in the regulation of mitochondrial functions, including energy production and apoptosis. As a chaperone, TRAP1 assists in the proper folding of mitochondrial proteins, maintaining mitochondrial homeostasis. Its role in cellular stress response makes TRAP1 a key player in protecting cells from various stressors, including oxidative stress. Research on TRAP1 explores its functions in mitochondrial biology, cellular stress adaptation, and its potential implications in diseases such as cancer, where mitochondrial dysfunction is often observed.
Amino acids 60-308 form the expressed segment for recombinant Human TRAP1. The theoretical molecular weight of the TRAP1 protein is 54.5 kDa. This TRAP1 recombinant protein is manufactured in e.coli. The N-terminal GST tag was fused into the coding gene segment of TRAP1, making it easier to detect and purify the TRAP1 recombinant protein in the later stages of expression and purification.The human heat shock protein 75 kDa, mitochondrial (TRAP1) is a molecular chaperone located in the mitochondria. TRAP1 belongs to the HSP90 family and plays a critical role in mitochondrial protein folding, stability, and cellular stress response. TRAP1 is involved in the regulation of mitochondrial functions, including energy production and apoptosis. As a chaperone, TRAP1 assists in the proper folding of mitochondrial proteins, maintaining mitochondrial homeostasis. Its role in cellular stress response makes TRAP1 a key player in protecting cells from various stressors, including oxidative stress. Research on TRAP1 explores its functions in mitochondrial biology, cellular stress adaptation, and its potential implications in diseases such as cancer, where mitochondrial dysfunction is often observed.
| Cat.No | ACP02991 | Target Name | TRAP1 |
|---|---|---|---|
| Target Synonyms | Heat shock protein 75 kDa; Heat shock protein 75 kDa, mitochondrial; HSP 75; HSP75; HSP90L; mitochondrial; TNF receptor associated protein 1; TNFR-associated protein 1; TRAP-1; Trap1; TRAP1_HUMAN; Tumor necrosis factor type 1 receptor-associated protein | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 60-308aa |
| Mol Weight | 54.5kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q12931 |
|---|
Uniprot Id
Q12931
Target Species
Human
Target Name
TRAP1
Target Full Name
Heat shock protein 75 kDa, mitochondrial
Target Function
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
Target Subcellular Location
Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix.
Target Protein Families
Heat shock protein 90 family
Target Tissue Specificity
Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors.
Target Research Area
Others
Target Synonyms
Heat shock protein 75 kDa; Heat shock protein 75 kDa, mitochondrial; HSP 75; HSP75; HSP90L; mitochondrial; TNF receptor associated protein 1; TNFR-associated protein 1; TRAP-1; Trap1; TRAP1_HUMAN; Tumor necrosis factor type 1 receptor-associated protein
Target Background
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants.
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