Recombinant Human Hemoglobin subunit gamma-2 (HBG2)

Uniprot Id

P69892

Target Species

Human

Target Name

HBG2

Target Full Name

Hemoglobin subunit gamma-2

Target Function

Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.

Target Involvement

Cyanosis transient neonatal (TNCY)

Target Protein Families

Globin family

Target Tissue Specificity

Red blood cells.

Target Research Area

Cardiovascular

Target Synonyms

Abnormal hemoglobin; FLJ76540; G gamma globin; Gamma 2 globin; Gamma-2-globin; Hb F Ggamma; HBG 2; HBG2; HBG2_HUMAN; Hemoglobin gamma 2 chain; Hemoglobin gamma G; Hemoglobin gamma G chain; Hemoglobin gamma-2 chain; Hemoglobin gamma-G chain; Hemoglobin subunit gamma 2; Hemoglobin subunit gamma-2; Methemoglobin; OTTHUMP00000069638

Target Background

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.