Recombinant Human Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial (COQ3)

Uniprot Id

Q9NZJ6

Target Species

Human

Target Name

COQ3

Target Full Name

Ubiquinone biosynthesis O-methyltransferase, mitochondrial

Target Function

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

Target Subcellular Location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Target Protein Families

Class I-like SAM-binding methyltransferase superfamily, UbiG/COQ3 family

Target Synonyms

COQ3; UG0215E05Ubiquinone biosynthesis O-methyltransferase; mitochondrial; 3-demethylubiquinol 3-O-methyltransferase; EC 2.1.1.64; Polyprenyldihydroxybenzoate methyltransferase; EC 2.1.1.114

Target Background

Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3, 4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.