Recombinant Human Hexokinase-1

Cat.No	ACP09393	Target Name	HK1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	476-917aa	Mol Weight	65.2kD
Protein Length	Catalytic	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP09393

Target Name

HK1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

476-917aa

Mol Weight

65.2kD

Protein Length

Catalytic

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P19367

Background Information

Uniprot Id

P19367
Target Species

Human
Target Name

HK1
Target Full Name

Hexokinase-1
Target Function

Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine. Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome.
Target Involvement

Hexokinase deficiency (HK deficiency); Neuropathy, hereditary motor and sensory, Russe type (HMSNR); Retinitis pigmentosa 79 (RP79)
Target Subcellular Location

Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasm, cytosol.
Target Protein Families

Hexokinase family
Target Tissue Specificity

Isoform 2: Erythrocyte specific (Ref.6). Isoform 3: Testis-specific. Isoform 4: Testis-specific.
Target Research Area

Metabolism
Target Synonyms

BB404130; Brain form hexokinase; dea; DrHXK1; EC 2.7.1.1; Glycolytic enzyme ; HEXOKIN; hexokinase I; Hexokinase PI; Hexokinase type I; Hexokinase; tumor isozyme; Hexokinase-1; Hexokinase-A; HK I; HK1; HK1 tb; HK1 tc; Hk1-s; HK1-ta; HK1-tb; HK1-tc; HKD; HKI; HMSNR; HXK1; HXK1_HUMAN; im:7148527; mHk1-s; wu:fc09d08; wu:fc16e02; wu:fc21e02; wu:fq14b11; zgc:55790; zgc:77618
Target Background

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific.

Recombinant Human Hexokinase-1

Specifications

Immunogen Information

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